Figure 3. Bioenergetics-, inflammation- and AD pathology-related gene expression.

A. Heatmaps of standardized gene expression from selective functional groups. Each gene was normalized and colored based on its relative expression levels across 5 biological groups. This method allows genes that have different magnitude of signal intensity but belong to the same functional group and share similar expression patterns to be displayed on the same heatmap. B. The first principal component (PC1) scores of the bioenergetic gene category for each animal group. The middle line in the box is the median, the ends of the box are 25^th and 75^th percentiles; the ends of the dotted lines are the 25/75 percentile + 1.5 times the interquartile range. C. Mutual correlations between different gene categories (Bioenergetics, Redox, Inflammation, Lipid metabolism and AD pathology) based on PC1 scores from the PCA of gene expression data. The r-value and significance for each of the Pearson’s correlation was summarized in the table. n = 5, * p ≤ 0.05; ***p ≤ 0.001.