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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Amino Acids. 2011 Aug 4;42(0):507–518. doi: 10.1007/s00726-011-1023-y

Fig. 3.

Fig. 3

Treatment of MHC-ODC mice with inhibitors of arginase or NOS

MHC-ODC mice were treated with daily ISO injections (20 mg/kg i.p.) for 10 days. Mice also received one of the following: 5% L-Arg in the drinking water from three days prior to ISO injections until the end of the experiment; 50 mg/kg (i.p.) Nor-NOHA daily from 3 days prior to ISO treatment until the end of the experiment; L-Arg/ISO plus 10 mg/kg (i.p.) SMT daily from one day prior to ISO treatment until the end of the experiment; Nor-NOHA/ISO plus 10 mg/kg (i.p.) SMT daily from one day prior to ISO treatment until the end of the experiment. N = number of mice in each group on Day 0. Statistical analysis of curves using log rank test showed that L-Arg/ISO survival curve is significantly different compared to L-Arg/ISO + SMT and Nor-NOHA/ISO + SMT curves (p < 0.03). Nor-NOHA/ISO curve is not different from L-Arg/ISO survival curve.