Table 4.

Functional magnetic resonance imaging activations during feedback evaluation

		Reward v. neutral feedback
		Healthy controls				Subjects with schizophrenia
		Peak t test	Talairach coordinates			Peak t test	Talairach coordinates
	BA	value	x	y	z	value	x	y	z
Right ventral striatum		4.09a	12	5	1
Left ventral striatum		4.87a	−12	2	1	4.22a	−12	2	1
Left mesial prefrontal cortex	32	5.85	0	15	28	5.73	−3	9	34
Left anterior cingulate	24	6.81	−6	−5	34	5.10	0	18	36
Right orbitofrontal cortex	47	9.04	39	16	−3	4.64	39	14	−4
Right temporal pole	38	7.61	50	10	−10	4.46	56	13	−8
Right insula	13					5.63	39	−1	6
Left insula	13					8.65	−39	−1	1
Right cerebellar vermis		7.08	15	−55	−39	7.33	6	−61	−26
Left cerebellar vermis						5.96	0	−64	−36
Right postcentral gyrus	43	6.59	62	−17	21	6.53	62	−18	16

BA, Brodmann area.

Brain activation during reward feedback. All results are significant at p < 0.05, false discovery rate corrected for multiple comparisons except when otherwise specified.

^aSignificant family-wise error corrected for small volume.