Table 2.

Association between irisin and CPET parameters depending on different adjustment sets

	peakVO 2		VO 2 @AT		Oxygen pulse		Maximum power output
	ß coefficient (Stderr)	p	ß coefficient (Stderr)	p	ß coefficient (Stderr)	p	ß coefficient (Stderr)	p
Whole population
Men (n = 322)
adjusted for age, BMI, smoking	−97.43 (43.139)	0.02	−6.388 (26.278)	0.81	−0.463 (0.249)	0.06	−7.656 (3.258)	0.02
adjusted for age, BMI, smoking, glucose, total cholesterol	−108.2 (43.752)	0.01	−11.48 (26.618)	0.67	−0.544 (0.252)	0.03	−8.434 (3.305)	0.01
Women (n = 418)
adjusted for age, BMI, smoking	27.580 (23.166)	0.23	0.981 (13.347)	0.94	0.054 (0.149)	0.72	−1.296 (1.872)	0.49
adjusted for age, BMI, smoking, glucose, total cholesterol	25.103 (23.337)	0.28	−0.805 (13.436)	0.95	0.021 (0.150)	0.89	−1.410 (1.887)	0.46
Subpopulation of subjects with a maximal time-lag between blood sampling and pulmonary function testing of one month
Men (n = 177)
adjusted for age, BMI, smoking	−96.07 (58.396)	0.10	4.926 (35.355)	0.89	−0.442 (0.335)	0.19	−8.720 (4.413)	0.05
adjusted for age, BMI, smoking, glucose, total cholesterol	−116.9 (60.121)	0.05	2.569 (36.563)	0.94	−0.557 (0.342)	0.11	−9.979 (4.557)	0.03
Women (n = 225)
adjusted for age, BMI, smoking	80.507 (27.836)	<.01	24.328 (18.694)	0.19	0.455 (0.177)	0.01	1.839 (2.302)	0.43
adjusted for age, BMI, smoking, glucose, total cholesterol	80.805 (28.106)	<.01	22.367 (18.856)	0.24	0.446 (0.179)	0.01	1.775 (2.326)	0.45

BMI = body-mass index; peakVO₂ = highest 10-second average of VO₂ in the last minute of exercise; VO₂@AT = VO₂ at anaerobic threshold. All models were further adjusted for time between core examination and pulmonary function testing and month of core examination.