Table 1.
Confocal analysis of Fgf lineage cells at E18.5 and P40
| Fgf8 CreER/+ | Fgf17 CreER/+ | |||||||
|---|---|---|---|---|---|---|---|---|
| Structure | Age | Marker | Double positive/βgal + | Double positive/marker + | n | Double positive/βgal + | Double positive/marker + | n |
| Cortex | P40 | PV (medial) | 2% | 10% | 2 | 0% | 0% | 2 |
| P40 | PV (lateral) | 4% | 12% | 2 | 3% | 1% | 2 | |
| P40 | SS (medial) | 2% | 6% | 2 | 0% | 0% | 2 | |
| P40 | SS (lateral) | 6% | 17% | 2 | 0% | 0% | 2 | |
| Septum | E18.5 | Calbindin | 2% | 60% | 1 | 17% | 23% | 1 |
| E18.5 | Calretinin | 16% | 58% | 1 | 24% | 19% | 1 | |
| E18.5 | Ctip2 | 24% | 69% | 1 | 15% | 9% | 1 | |
| E18.5 | Nkx2.1 | 5% | 74% | 1 | 19% | 20% | 1 | |
| P40 | ChAT (MS) | 8% | 77% | 2 | 17% | 33% | 4 | |
| Diagonal band of Broca | E18.5 | Calbindin | 10% | 50% | 1 | 6% | 19% | 1 |
| E18.5 | Nkx2.1 | 2% | 33% | 1 | 9% | 26% | 1 | |
| E18.5 | Tbr1 | 34% | 95% | 1 | 59% | 41% | 1 | |
| P40 | ChAT | 13% | 80% | 2 | 28% | 44% | 4 | |
| Striatum | P40 | ChAT | 23% | 66% | 3 | 64% | 16% | 3 |
| P40 | Ctip2 | 70% | 9% | 3 | nd | nd | nd | |
| P40 | PV | 1% | 14% | 2 | 0% | 0% | 2 | |
| P40 | SS | 2% | 29% | 2 | nd | nd | nd | |
| Globus pallidus | E18.5 | Ctip2 | 96% | 35% | 1 | 71% | 3% | 1 |
| E18.5 | Nkx2.1 | 92% | 37% | 1 | 89% | 4% | 1 | |
| P40 | Npas1 | 72% | 28% | 3 | 88% | 5% | 2 | |
| P40 | PV | 46% | 38% | 2 | 0% | 0% | 2 | |
| Nucleus basalis of Meynert | P40 | ChAT | 49% | 75% | 3 | 92% | 43% | 3 |
| Ventral pallidum | P40 | ChAT | 42% | 76% | 3 | 95% | 45% | 3 |
Quantification of confocal studies examining co-localization of βgal with cell type-specific markers in Fgf8 CreER/+; TauR and Fgf17 CreER/+; TauR animals (Tm E8.5). Parenthetical descriptors (lateral, medial, MS) indicate regional location within the structure. See also Additional file 4: Figures S4 and Additional file 5: Figure S5. Cortical interneuron counts are overestimates, as quantification was done only in regions containing βgal+ cells.