Table 1.
Respiratory and hemodynamic variables according to the presence or absence of ACP and/or PFO a
| Parameters | PFO and ACP | PFO only | ACP only | No PFO and no ACP | P value |
|---|---|---|---|---|---|
| (n = 8) | (n = 21) | (n = 36) | (n = 130) | ||
| VT/predicted body weight (mL/kg) | 6.5 [5; 7] | 6 [5; 7] | 6.5 [6; 8] | 6 [5; 7] | 0.64 |
| PEEP (cmH2O) | 10 [6; 13] | 10 [8; 12] | 10 [8; 14] | 11 [8; 12] | 0.36 |
| Driving pressure (cmH2O)b | 15 [13; 16] | 16 [13; 17] | 15 [12; 20] | 14 [11; 17] | 0.22 |
| PaO2/FiO2 | 95 [75; 115] | 107 [71; 153] | 114 [72; 145] | 112 [91; 154] | 0.33 |
| PaCO2 (mmHg) | 47 [40; 62] | 48 [41; 52] | 50 [44; 58] | 45 [39; 53] | 0.28 |
| Heart rate (bpm) | 106 [91; 116] | 105 [97; 128] | 97 [85; 113] | 100 [85; 116] | 0.29 |
| mBP (mmHg) | 79 [70; 85] | 79 [70; 89] | 80 [74; 88] | 81 [73; 90] | 0.80 |
| CVP (mmHg) | 11 [10; 13] | 11 [10; 12] | 11 [10; 14] | 10 [9; 12] | 0.96 |
| Lactates (mmol/L) | 1.3 [1.2; 1.9] | 1.3 [1; 2] | 1.3 [1; 2.1] | 1.4 [1.1; 2] | 0.93 |
| Prone positioning (n) | 2 (25%) | 3 (14%) | 18 (50%) | 44 (34%) | 0.04 |
| Nitric oxide (n) | 3 (38%) | 2 (10%) | 6 (17%) | 14 (11%) | 0.15 |
| Vasopressor support (n) | 6 (75%) | 10 (48%) | 18 (50%) | 62 (48%) | 0.55 |
| 28-day mortality (n) | 1 (13%) | 6 (29%) | 9 (25%) | 29 (22%) | 0.82 |
aResults are expressed as median values with 25th to 75th percentiles unless otherwise stated; bdefined as the difference between the inspiratory plateau pressure and positive end-expiratory pressure. ACP, acute cor pulmonale; PFO, patent foramen ovale; VT, tidal volume; PEEP, positive end-expiratory pressure; PaO2, partial pressure of arterial oxygen; FiO2, fraction of inspired oxygen; PaCO2, partial pressure of arterial carbon dioxide; mBP, mean blood pressure; CVP, central venous pressure.