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Proinflammatory cytokine response in cell lines. IL-8 levels in wild-type (WT) and mutant TNFRSF1A HEK-293 unstimulated (white columns) or stimulated (black columns) for 4 hours at 37°C with TNF (6 ng/mL). Data displayed as mean ± SEM. *P <0.005; **P <0.001; ***P <0.0001 respect to WT.
