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. 2014 Sep 25;6:104. doi: 10.1186/1758-5996-6-104

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© Ezrokhi et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of timed daily bromocriptine administration on ventromedial hypothalamic catecholamines. A. SHR rats exhibited elevated VMH NE release relative to Wistar normal controls (P < 0.0001). Timed daily bromocriptine administration significantly reduced VMH MHPG of SHR rats compared with vehicle treated SHR rats (P < 0.0001). B. SHR rats exhibited significantly lower extracellular VMH HVA content compared with normal Wistar rats (p < 0.001). C. SHR rats exhibited elevated VMH 5-HIAA release relative to Wistar normal controls (P < 0.0001). Timed daily bromocriptine administration significantly reduced VMH 5-HIAA of SHR rats compared with vehicle treated SHR rats (P < 0.0001) There was no significant difference in VMH 5-HIAA levels between SHR BC treated and Wistar rats.