Table 4. Rat PK Profiles and Plasma Protein Binding Data in Human and Rat Plasma (10%)^a.

compd	F%	Clp (mL/min/kg)	Vdss (L/kg)	T1/2 (h)	AUCNpo (μM·h·kg/mg)	free fraction in 10% plasma (%, human, rat)
2a	15	47	4.6	1.5	0.11	0.2, 1
2d	36	33	3.4	1.7	0.33	0.2, 0.7
2f	6	32	1.8	1.6	0.067	3.4, 6.4
2m	27	19	1.6	1.8	0.49	4, 1.7
2o	54	20	1.9	1.2	0.79	-
2p	44	67	2.3	0.69	0.07	9.3, 6.5
2q	11	80	5.0	0.94	0.046	0.2, 0.8
3c	44	23	3.4	2.4	0.067	0.2, 0.5
3e	15	55	3.2	1.2	0.085	5.8, 6.4

^aValues are an average of two wistar han rats for IV dose and three rats for p.o. dose. Formulation: The IV doses were formulated at 1 mg/kg in DMSO/PEG200/water (10:60:30), and the oral doses were formulated at 2 mg/kg in imwitor/tween (1:1) and given by oral gavage. F%, oral bioavailability; Cl_p, plasma clearance; V_dss, volume of distribution; C_max, observed maximal plasma concentration following oral dosing; T_1/2, terminal half-life; AUCN_po; normalized area under the curve for oral dosing.