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. 2015 May 1;9:102. doi: 10.3389/fnbeh.2015.00102

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Copyright © 2015 Seffer, Rippberger, Schwarting and Wöhr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Post-weaning but not post-adolescent social isolation leads to a lack of approach behavior in response to pro-social 50-kHz USV that can be reversed by re-socialization: within-group comparisons. (A–C) Line graphs depicting changes in side preferences as assessed by the time spent [s/min] on proximal (black) and distal (white) arms displayed by rats exposed to 4 weeks of (A) NO ISO, (B) SHORT ISO, and (C) LONG ISO, post-weaning, during the baseline period (5 min; PRE) and during playback (1 min; DUR) in response to 50-kHz USV in Experiment 1: Post-weaning Social Isolation—Effects. (D–F) Line graphs depicting changes in side preferences as assessed by the time spent [s/min] on proximal (black) and distal (white) arms displayed by rats exposed to 4 weeks of (D) NO ISO, (E) SHORT ISO, and (F) LONG ISO, post-weaning, plus one additional week of peer rearing, during the baseline period (5 min; PRE) and during playback (1 min; DUR) in response to 50-kHz USV in Experiment 2: Post-weaning Social Isolation—Rescue. (G–I) Line graphs depicting changes in side preferences as assessed by the time spent [s/min] on proximal (black) and distal (white) arms displayed by rats exposed to 4 weeks of (G) NO ISO, (H) SHORT ISO, and (I) LONG ISO, post-adolescent, during the baseline period (5 min; PRE) and during playback (1 min; DUR) in response to 50-kHz USV in Experiment 3: Post-adolescent Social Isolation—Effects. ^*p < 0.050 compared to distal arm time.