Table 1.
List of cell parameters, crystallite size, loading and release profiles for ion substituted CDHAs.
| Sample code | % ionic substitution | Cell parameters (Å) |
Cell volume (Å)3 | Average crystallite size (nm) |
Doxycycline loading percentage (%) (mean ± SD) | Doxycycline release percentage (%) (mean ± SD) | ||
|---|---|---|---|---|---|---|---|---|
| a | c | XRD | TEM (mean ± SD) | |||||
| CDHA | – | 9.110 | 6.80 | 519 | 25 | (41 ± 0.6) × (5 ± 0.1) | 68 ± 9 | 61 ± 1.0 |
| ZnCDHA | 6 | 9.014 | 6.72 | 509 | 19 | (39 ± 0.7) × (4 ± 0.3) | 47 ± 8 | 57 ± 1.2 |
| 0.25AgCDHA | 0.25 | 9.190 | 6.82 | 524 | 27 | (41 ± 0.5) × 6 ± 0.3) | 37 ± 4 | 49 ± 1.6 |
| 0.5AgCDHA | 0.5 | 9.195 | 6.81 | 527 | 28 | (42 ± 0.9) × (6 ± 0.4) | 30 ± 3 | 52 ± 0.8 |
| 0.75AgCDHA | 0.75 | 9.198 | 6.83 | 529 | 29 | (44 ± 0.5) × (6 ± 0.4) | 27 ± 5 | 55 ± 0.8 |
| 2.5SrCDHA | 2.5 | 9.410 | 6.80 | 541 | 34 | (47 ± 0.5) × (6 ± 0.3) | 31 ± 6 | 51 ± 1.1 |
| 5SrCDHA | 5 | 9.440 | 6.82 | 547 | 38 | (49 ± 0.4) × (6 ± 0.2) | 26 ± 5 | 54 ± 0.7 |
| 7.5SrCDHA | 7.5 | 9.460 | 6.83 | 549 | 38 | (51 ± 0.2) × (6 ± 0.2) | 21 ± 6 | 56 ± 0.9 |