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EC50 values of subtype-selective blockers of voltage-gated sodium channels
| EC50 | NaV1.6 | NaV1.7 | NaV1.8 | Reference |
|---|---|---|---|---|
| TTX | 1–6 | 4 | 60,000,000 | Catterall et al. 2005 |
| PTX | 26 | 0.3 | 146 | Schmalhofer et al. 2008 |
| mCtxG | 680 | >100,000 | >100,000 | Wilson et al. 2011 |
| mCtxP | 100 | >100,000 | >100,000 | Wilson et al. 2011 |
| A803 | 6,740 | 6,740 | 140 | Jarvis et al. 2007 |
Values are in nM. TTX, tetrodotoxin; PTX, ProTx-II; mCtxG, μ-conotoxin GIIIa; mCtxP, μ-conotoxin PIIIa; A803, A803467.
