Fig. 6.

Dorsal CA1 neurons have an A1AR-mediated GIRK conductance. A: representative voltage responses with step current commands at RMP. B: time courses of changes in V_m and R_in during successive 50 μM Ba²⁺ and 100 nM DPCPX in dorsal CA1 neurons. Dorsal CA1 neurons showed a significantly depolarized V_m (C) and an increased R_in (D) at RMP in the presence of Ba²⁺. Subsequent bath application of DPCPX had no further effects on V_m (C) and R_in (D) at RMP in dorsal neurons. E, left: representative voltage responses with step current commands at −73 mV. Successive Ba²⁺ and DPCPX application led to a significantly increased R_in at a common V_m (−73 mV). *P < 0.05.