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. 2015 Feb 11;113(7):2953–2966. doi: 10.1152/jn.01056.2014

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Fig. 2. — A: representative traces of miniature excitatory postsynaptic currents (mEPSCs) from striatal MSNs at 2 (A1), 7 (A2), and 12 (A3) mo for WT, Q175^+/−, and Q175^+/+ mice at a V_Hold of −70 mV in the presence of 10 μM BIC and 1 μM tetrodotoxin (TTX). B: amplitude-frequency histograms for WT, Q175^+/−, and Q175^+/+ mice at 2 (B1), 7 (B2), and 12 (B3) mo. Significant decreases in frequency occurred in 5–10 and 10–15 pA bins at both 7 and 12 mo for both Q175^+/− and Q175^+/+ mice. The average frequency of mEPSCs (insets) was reduced significantly for both Q175^+/− and Q175^+/+ mice compared with WTs at 7 mo and for Q175^+/− compared with WTs at 12 mo. C: cumulative interevent interval histograms for WT, Q175^+/−, and Q175^+/+ mice at 2 (C1), 7 (C2), and 12 (C3) mo. Histograms were significantly shifted to the right for both Q175^+/+ and Q175^+/− compared with WTs at both 7 and 12 mo, indicating a higher proportion of occurrence of longer interevent intervals.