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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Eur J Nucl Med Mol Imaging. 2009 Mar 4;36(8):1273–1282. doi: 10.1007/s00259-009-1089-x

Fig. 5.

Fig. 5

MicroPET imaging comparison of HSV1-R176Qsr39tk and HSV1-A167Ysr39tk reporter gene expression in the same animal. a A representative animal bearing a HSV1-R176Qsr39tk- (right shoulder) and a HSV1-A167Ysr39tk- (left shoulder) expressing xenograft was imaged with 18F-FEAU and 18F-FHBG on 2 consecutive days. Axial (transverse) and coronal sections through the tumors are shown. All images were adjusted to the same color scale. High specific 18F-FEAU accumulation was observed in the HSV1-R176Qsr39tk+ xenograft and high specific accumulation of 18F-FHBG was observed in theHSV1-A167Ysr39tk xenograft. Slight 18F-FHBG accumulation was also observed in HSV1-R176Qsr39tk-expressing xenograft. Note radiotracer clearance from gut and bladder. b Image-based measurements of 18F-FEAU and 18F-FHBG at 2 h after radiotracer administration expressed as % injected dose/cc of tissue (%ID/cc, n=5). Values are the mean±SD. N/T non-transduced