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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Neurogastroenterol Motil. 2014 Apr 11;26(6):832–840. doi: 10.1111/nmo.12337

Figure 1.

Figure 1

Raw data (upper) and histogram summary (lower) of cardiac interbeat interval (IBI) in 4 representative healthy premature infants (upper traces) who remained healthy throughout the study duration. The lower traces show the raw data (upper) and summary histogram (lower) of IBI in 4 healthy premature infants who developed NEC (using Bell’s stage II+ criteria) 0.5-20 days later. Note that the healthy premature infants had a larger IBI variability and a broader distribution of events whereas premature healthy infants that went on to develop NEC had much less IBI variability and sharper event distribution even before NEC was clinically diagnosed. All the “healthy” infants which later developed NEC were identified by the lower IBI variability and HF-power. The representative subjects selected for comparison (“healthy” and “healthy prior to NEC”) were matched for gestational age and morbidity index at birth.