Table 2. Description of the malaria vaccine trials.
| Trial details | Ghana: RTS,S phase III malaria vaccine trial | Kenya: RTS,S phase III malaria vaccine trial | Burkina Faso: GMZ2 phase II b malaria vaccine trial |
|---|---|---|---|
| Trial duration | March 2009 – January 2014 | May 2009 – January 2014 | April 2011 – July 2013 |
| Children recruited (age/number) | 1,333 healthy children: 5–17 months (n = 1002), 6–12 weeks (n = 331) | 904 healthy children: 5–17 months (n = 600), 6–12 weeks (n = 304) | 580 healthy children:12–60 months (n = 580) |
| Trial location | Kintampo North and Kintampo South Districts | Ganze District, Kilifi County | Banfora District |
| Government facilities involved; distance from clinical trial facility (km/m)* | 3 health centres: 19 km, 47 km and 51 km from KHRC | 2 dispensaries; 27 km and 38 km from KWTRP | - 2 community clinics (CSPS) a ; 5 km and 7 km from CRUB b |
| Kintampo North Municipal hospital: 50 m from KHRC | 1 health centre; 30 km from KWTRP | ||
| 1 county hospital; same location with KWTRP | |||
| Role of primary care facilities in the MVT | 3 health centres: recruitment sites; patient monitoring; provision of patient care during and outside working hours; MVT vaccination centre | 1 health centre and 2 dispensaries: recruitment sites; patient monitoring; provision of patient care during and outside working hours; MVT vaccination centre | 2 community clinics: recruitment sites; patient monitoring; provision of patient care during and outside working hours; station for picking and dropping participants for scheduled visits at the CRUB |
| Role of tertiary/ referral facilities in the MVT | Kintampo North Municipal hospital: study participants referral and in-patient care; provide oversight and support for existing MoH staff in MVT; MVT vaccination centre | Kilifi County hospital: study participants referral and in-patient care; provide oversight and support for existing MoH staff in MVT | CRUB: study participants referral and in-patient care; provide oversight and support for existing MoH staff in MVT; MVT vaccination centre |
| Facilities with prior research/CT involvement | Kintampo North Municipal hospital, conducted other inpatient CTs | Kilifi County Hospital, conducted other inpatient CTs | CRUB, conducted other malaria vaccine and drug CTs |
| 1 health centre, site within HDSS | 2 community clinics, sites within HDSS | ||
| Facilities with no prior research/CT involvement | 2 health centres, sites within HDSS | 1 health centre and 2 dispensaries, sites outside HDSS |
*km/m: kilometre/metre;
a CSPS: Centre de Santé et de Promotion Sociale;
b CRUB: clinical research unit of Banfora.