Table 1. Characteristics of Autopsy Subjects.
| All autopsies | LBD | ADLBV | AD | Control | Total | |
|---|---|---|---|---|---|---|
| N | 59 | 68 | 71 | 33 | 231 | |
| Male | % | 71.2 | 52.9 | 36.6 | 54.5 | 52.8 |
| Age at Dementia (yr) | Mean | 66.6 | 67.6 | 70.7 | 68.4 | |
| SD | 10.3 | 9.6 | 8.5 | 9.5 | ||
| Age at Death (yr) | Mean | 78.3 | 79.1 | 81.6 | 70.3 | 78.4 |
| SD | 8.7 | 8.5 | 8.6 | 14.2 | 10.1 | |
| Duration (yr) | Mean | 11.6 | 10.3 | 10.0 | 10.6 | |
| SD | 6.1 | 6.1 | 4.3 | 5.5 | ||
| Education (yr) | Mean | 16.6 | 14.1 | 13.8 | 14.2 | 14.5 |
| SD | 2.3 | 4.1 | 4.3 | 3.4 | 4.0 | |
| Ethnicity | % White | 94.9 | 86.8 | 85.9 | 60.6 | 84.8 |
| %AJ ancestry | N (individuals) | 3 | 7 | 15 | 2 | 27 |
| % AJ (n/total samples with GWAS) | 100(3/3) | 35 (7/20) | 41.67 (15/36) | 66.67 (2/3) | 43.5** (27/62) | |
| LB Pathology Present | % | 100.0 | 100.0 | 16.9 | 3.0 | 60.6 |
| LB Cortical Pathology Present | % | 100.0 | 100.0 | 0.0 | 0.0 | 55.0 |
| LB Subcortical Pathology Present | % | 64.4 | 69.1 | 12.7 | 0.0 | 40.7 |
| AD Pathology Present | % | 79.7 | 100.0 | 100.0 | 33.3 | 85.3 |
| AD Pathological Diagnosis | % | 0.0 | 100.0 | 100.0 | 0.0 | 60.2 |
| GBA mutation | N(Individuals) | 28 | 16 | 6 | 1 | 51 |
| % | 47.5 | 23.5 | 8.5 | 3.0 | 22.1 | |
| SMPD1 mutation | N(Individuals) | 12 | 14 | 4 | 3 | 33 |
| % | 20.3 | 20.6 | 5.6 | 9.1 | 14.3 | |
| HEXA mutation | N(Individuals) | 8 | 17 | 8 | 6 | 39 |
| % | 13.6 | 25.0 | 11.3 | 18.2 | 16.9 | |
| MCOLN1 mutation | N(Individuals) | 17 | 20 | 17 | 8 | 62 |
| % | 28.8 | 29.4 | 23.9 | 24.2 | 26.8 | |
| APOE (no E4)* | N(Individuals) | 33 | 26 | 26 | 24 | 109 |
| % | 66.0 | 41.9 | 42.6 | 77.4 | 47.2 | |
| APOE (one E4) * | N(Individuals) | 13 | 26 | 25 | 6 | 70 |
| % | 26.0 | 41.9 | 41.0 | 19.4 | 30.3 | |
| APOE (two E4) * | N(Individuals) | 4 | 10 | 10 | 1 | 25 |
| % | 8.0 | 16.1 | 16.4 | 3.2 | 10.8 | |
* APOE missing in 27cases
**%AJ in brain autopsy sample with GWAS data available (n = 62)