Table 1. Summary of candidate gene validation experiments.
RNAi Driver | |||||
---|---|---|---|---|---|
Candidate Gene | GWAS Association | Exelixis (T5/T6) | tub-GAL4 (T5/T6) | pnr-GAL4 (T5/T6) | ubi-GAL4 (T5/T6) |
CG33298 | T6 | NS/NS | NS/NS | NS/NS | - |
Fish-lips (Fili) | T6 | ↑/↑ | lethal (♀ only) | lethal (♀ only) | - |
Vesicular monoamine transporter (Vmat) | T6 | - | lethal | NS/NS | lethal |
multiple wing hairs (mwh) | T6 | NS/NS | NS/NS | NS/NS | - |
Kinesin-like protein at 61F (Klp61F) | T6 | NS/NS | lethal | NS/↑ | lethal |
CG9134 | T6 | ↑/↑ | ↓/↓ | NS/NS | - |
CG7852 | T6, T5-T6 | ↑/↓ | lethal | NS/↓ | lethal |
CG1887 | T6 | - | lethal | NS/NS | ↓/NS |
klarsicht (klar) | T6 | NS/↓ | lethal | NS/↑ | ↑/↑ |
Glucose transporter 1 (Glut1) | T6 | ↑/↑ | - | - | - |
Exchange factor for Arf 6 (Efa6) | T6 | ↑/↑ | ↑/↑ | NS/↑ | - |
buttonless (btn) | T6 | - | ↓/↓ | NS/↓ | - |
roughoid (ru) | T5 | - | lethal | ↓/↓ | lethal |
CG10625 | T5 | NS/↓ | ↓/↓ | NS/NS | - |
sinuous (sinu) | T5 | - | lethal | ↓/↓ | lethal |
Sucb (Sucb) | T5 | NS/↓ | - | - | - |
division abnormally delayed (dally) | T5 | NS/↓ | NS/NS | NS/NS | - |
CG32052 | T5 | - | NS/NS | NS/NS | - |
Nedd2-like caspase (Nc) | T5 | - | lethal | NS/NS | lethal |
Ceramide kinase (Cerk) | T5 | - | NS/NS | NS/NS | - |
krotzkopf verkehrt (kkv) | T5 | ↓/↓ | lethal | lethal | lethal |
CG15803 | T5 | - | NS/NS | NS/NS | - |
locomotion defects (loco) | T5 | NS/↓ | ↑/↑ | NS/NS | - |
TweedleC (TwdlC) | T5 | - | NS/NS | NS/NS | |
kayak (kay) | T5 | NS/↓ | lethal | NS/NS | lethal |
CG1340 | T5 | - | NS/NS | NS/NS | - |
CG42594 | T5 | - | NS/NS | NS/NS | - |
CG42340 | T5 | - | lethal | NS/NS | lethal |
NS = not significant,"–" = line not available or RNAi cross not tested. ↑ = increased pigmentation. ↓ = decreased pigmentation.