Skip to main content
. 2015 Apr 13;194(10):5014–5021. doi: 10.4049/jimmunol.1402991

FIGURE 4.

FIGURE 4.

Histamine facilitates maturation of DCs and myelomonoblastic cells via H2Rs. (A) ROS production by human monocytes stimulated with fMLF alone (open bar) or fMLF in the presence of histamine (his; 100 μM), ranitidine (rani; 10 μM), AH20239AA (AH; 10 μM), or N-methyl histamine (NMH; 100 μM) (n = 3). (B) CD86 expression (MFI) on DCs and monocytes cultured in the presence or absence of histamine (his) and/or ranitidine (rani). (C) CD11b expression (MFI) of PLB cells and NOX2-def PLB cells cultured with GM-CSF in the presence or absence of histamine (his) and/or ranitidine (rani). The medians and quartiles are indicated by boxes, and the error bars show the minimum to maximum values. *p < 0.05, ***p < 0.001 repeated-measures ANOVA and Bonferroni post hoc test.