Table 2. IC50 values for MitoVES and several other anti-cancer agents for parental and CD24- adherent and sphere Ist-Mes-2 cells.
| Anti-cancer agent | Adherent cells IC50 | Sphere cells IC50 | CD24- cells IC50 |
|---|---|---|---|
| Doxorubicin | 14.79±1.23 μM | 20.74±3.45 μM a | N.D. |
| 5FU | 1.325±0.27 mM | 1.325±0.27 mM | 1.042±0.74 mM |
| Tamoxifen | 27.95±0.3 μM | 29.30±0.14 μM | 29.85±0.11 μM |
| α-TOS | 40.8±0.28 μM | 108.3±5.50 μM | 42.33±0.28 μM |
| MitoVES | 25.83±1.47 μM | 6.924±.0.5 μM | 7.709±3.6 μM |
aNumbers in bold indicate significantly different data (p<0.05) from adherent CD24-and parental cells.
The data are mean values ± S.D. from three independent experiments.