Table 5. Rates and hazard ratios of AIDS associated with eGFR from fitting a Cox regression model.
Hazard Ratio (95% CI) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Baseline eGFR | No. AIDS events | PYFU | Rate/1000PYFU | 95% CI | Unadjusted | Adjusted(a) | Adjusted(b) | Adjusted(c) | Adjusted(d) |
>90 | 227 | 23880 | 9.51 | 8.35, 10.83 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
60–89 | 65 | 10754 | 6.04 | 4.74, 7.71 | 0.68 (0.52, 0.90) | 0.68 (0.51, 0.90) | 0.48 (0.32, 0.72) | 0.64 (0.47, 0.88) | 0.48 (0.31, 0.75) |
<60 | 19 | 759.4 | 25.0 | 15.96, 39.22 | 2.49 (1.56, 3.97) | 2.20 (1.35, 3.58) | 1.71 (0.89, 3.30) | 1.90 (1.12, 3.23) | 1.26 (0.57, 2.81) |
(a) Adjusted for age, gender mode of HIV transmission, ethnicity and calendar year of baseline
(b) Adjusted for smoking, diabetes mellitus,previous AIDS diagnosis, blood pressure lowering drugs,lipid lowering drugs, total cholesterol, blood glucose levelsand high density lipoprotein cholesterol
(c) Adjusted for ART-status, baseline CD4, CD8, nadir CD4, baseline HIV-RNA and co-infection with hepatitis B/C
(d) Adjusted for factors in footnotes a-c.