Fig 2. SL pairs are reflected in copy number variations.

SL pairs are less likely to have (a) homozygous co-loss events, (b) heterozygous co-loss events and (c) mixed co-loss events than non-SL pairs or random pairs. The fractions for these three types of co-loss events are described as f₁, f₂, f₃ in Methods and Fig 1. Each dot is the fraction for a given pair and the horizontal bar represents the mean of the fractions. P-values for the comparison between SL and non-SL pairs were calculated using one-sided Wilcoxon rank test. P-values for the comparison between SL and random pairs were calculated from 1000 randomizations. P-values were adjusted for multiple comparisons using the Bonferroni correction (see details in Methods).