Table 3. Summary of all variants in LCL, B95.8, and Jijoye samples compared to EBV-1 and EBV-2.
Variants vs. EBV-1 | ||||||||
Sample | Total | Insertion | Deletion | Substitution | Intergenic | Genic Noncoding | Coding Synonymous | Coding Non-Synonymous |
LCL1 | 968 | 19 | 20 | 929 | 511 | 232 | 136 | 87 |
LCL3 | 606 | 14 | 10 | 582 | 327 | 167 | 59 | 52 |
LCL9 | 969 | 22 | 22 | 925 | 496 | 242 | 137 | 92 |
LCL10 | 980 | 14 | 20 | 946 | 576 | 227 | 110 | 65 |
Common LCLs | 178 | 2 | 0 | 176 | 77 | 56 | 24 | 20 |
B95.8 | 73 | 5 | 5 | 63 | 39 | 8 | 10 | 16 |
Jijoye | 1234 | 13 | 24 | 1197 | 710 | 215 | 176 | 108 |
Common LCLs+ B95.8+Jijoye | 5 | 0 | 0 | 5 | 4 | 0 | 0 | 1 |
Variants vs. EBV-2 | ||||||||
LCL1 | 645 | 9 | 9 | 627 | 115 | 226 | 167 | 137 |
LCL3 | 597 | 8 | 11 | 578 | 96 | 226 | 150 | 125 |
LCL9 | 639 | 10 | 9 | 620 | 113 | 238 | 158 | 130 |
LCL10 | 316 | 5 | 9 | 301 | 57 | 117 | 88 | 53 |
B95.8 | 530 | 6 | 10 | 514 | 79 | 206 | 121 | 115 |
Jijoye | 423 | 3 | 5 | 415 | 90 | 129 | 123 | 81 |
Common LCLs 1,3,9 | 418 | 5 | 7 | 406 | 65 | 166 | 91 | 96 |
Common LCL10+ Jijoye | 176 | 1 | 2 | 173 | 20 | 50 | 69 | 37 |
Common LCLs 1,3,9+ B95.8 | 317 | 3 | 4 | 310 | 43 | 139 | 66 | 69 |
Common ALL LCLs | 85 | 0 | 2 | 83 | 15 | 18 | 28 | 24 |
Common ALL samples | 49 | 0 | 0 | 49 | 7 | 15 | 16 | 11 |
Summary of the mutations identified in the LCLs and control samples when compared to EBV-1, we noted that substitution was the most common type mutation, with Jijoye having the most and B95.8 having the least. Deletions and insertions were also observed ranging from 5 (B95.8) to 24 (Jijoye) and 5 (B95.8) and 13 (Jijoye) respectively. When compared to EBV-2 it is to be noted that substitution was the most common type of mutation, with LCL1 (627) having the most and LCL10 (301) having the least. Deletions and insertions were also observed ranging from 5 (Jijoye) to 11 (LCL-3) for deletion and 3 (Jijoye) to 10 (LCL-9) for insertion respectively.