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. 2015 Mar 23;290(18):11526–11536. doi: 10.1074/jbc.M115.641225

FIGURE 2.

FIGURE 2.

Inhibition of PI3K signaling reduced Sort1 protein in mouse livers. A, hepatic Sort1 protein in male 12-week-old WT and ob/ob mice. B and C, hepatic Sort1 protein (B) and mRNA (C) in vehicle- and STZ-treated mice. Real-time PCR results were expressed as mean ± S.E. (error bars) n = 4. D and E, male 12-week-old C57BL6J mice were intraperitoneally injected with PX866 (8 mg/kg) or vehicle (n = 4). After 8 h, liver Sort1 protein (D) and liver Sort1 mRNA (E) were measured. F, male 12-week-old C57BL6J mice were intraperitoneally injected with PX866 (8 mg/kg) or vehicle once daily for 3 days. After the last injection, mice were then fasted for 8 h, and pooled plasma (n = 4) was used for FPLC cholesterol analysis. P-AKT, phospho-AKT; T-AKT, total AKT.