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A proposed mechanism for MT severing by katanin p60. Katanin p60 seems to oligomerize on MTs A and B, simultaneous pulling of both C-terminal tails of α- and β-tubulins may generate mechanical tensions in the tubulin dimer (C), leading to destabilization of tubulin-tubulin contacts. The resulting defective interaction may promote the release the tubulin dimer (D). The released tubulins are competent to repolymerize.
