Fig 1. Activations of candidate proteins involved in P4-induced increases in the levels of p21^cip1 and p27^kip1 protein in RASMCs.

Treatment of RASMCs with P4 (50 nM) for 5 min increased the levels of p-cSrc, p-Raf-1, p-AKT, p-ERK1/2, and p-p38 protein (A) and membrane translocation of Kras, an indicator for Kras activation (B). Data are representative of 2 independent experiments with similar results. Values shown in parentheses represent the quantified results adjusted with their own total protein level (A) or with G3PDH (for cytosol protein) and cadherin (for membrane protein), and expressed as ratio over control. Con, control.