Skip to main content
. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Mol Cell Biochem. 2015 Mar 6;404(0):171–179. doi: 10.1007/s11010-015-2376-4

Figure 2.

Figure 2

ADAMTS-7 TG mice become more susceptible to CIA. (A) Real-time RT-PCR analysis of ADAMTS-7 mRNA expression from cartilage of TG mice and wide type control. (B) IHC was performed using paw joint sections. Scale bars, 200μm. (C) Total incidence of CIA in TG mice (n=9) compared to wild type littermate mice (n=9). (D) Representative photographs of hindpaws. (E and F) Representative micro-CT images of hindpaws, and BV/TV of bone destruction. (G) Disease severity were scored and recorded by visual examination of mouse paws. All data were expressed as means ±SD from three independent experiments, *P< 0.05, **P<0.01, ***P<0.001.