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. Author manuscript; available in PMC: 2016 May 15.
Published in final edited form as: Biol Psychiatry. 2014 Nov 13;77(10):903–911. doi: 10.1016/j.biopsych.2014.10.024

Figure 2.

Figure 2

Dopamine release encodes the relative value of cue presentations during delay discounting. Dopamine concentration aligned to cue onset (black bar, time 0 s) on forced large versus forced small reward trials during the (A) No Delay, (B) Short Delay, and (C) Long Delay blocks. (D) Peak dopamine concentration following cue onset for forced Large/Delay cues (black squares) and forced Small/Immediate cues (open squares) across each reward delay block. Dopamine release was greatest for the Large option when delivered immediately, but decreased as delays to reinforcement increased. *p<0.05 Large/Delay greater than Small/Immediate. ‡p<0.05 Large/Delay option less than Large/Delay (No Delay block). §p<0.05 Small/Immediate greater than Large/Delay. Data are mean ± SEM. (E) Correlation of behavioral preference (% Large/Delay option chosen within a block) with dopamine difference score (peak dopamine for the Large/Delay option minus peak dopamine for the Small/Immediate option within a block) for each animal during each of the three blocks of the task.