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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Trends Genet. 2015 Apr 4;31(5):232–238. doi: 10.1016/j.tig.2015.03.003

Figure 1. Development of three types of fat cells.

Figure 1

White, beige, and brown adipocytes are derived from different lineages and subpopulations of precursors. Brown adipocytes come from Myf5+/Pax7+ lineages, whereas white and beige adipocytes arise from Myf5−/Pax7− lineages. Recently, Myh11 expressing progenitors have been newly identified as a population giving rise to at least some of the “inducible” thermogenic beige adipocytes. PPARγ coordinates the adipogenesis of three types of fat cells through interactions with different transcriptional coregulators. TLE3 functions as a coactivator of PPARγ during white adipogenesis [70]. Recruitment of PRDM16 and EBF2 to PPARγ leadscells to differentiate into thermogenic beige and brown adipocytes.