Table 3.
Maternal serum angiogenic protein concentrations* at four time points during gestation; BIRTH Cohort
| Gestational weeks mean (range) | 9.7 (8.4–11.6) | 17.8 (16.8–18.7) | ||||
|---|---|---|---|---|---|---|
| Singleton | Twin | p-value | Singleton | Twin | p-value | |
| n=2193 | n=91 | n=2058 | n=89 | |||
| PlGF (pg/ml)* | 22.8 (22.4 – 23.2) | 24.9 (23.0 – 26.9) | 0.0323 | 138.4 (135.6 – 141.3) | 213.5 (193.3 – 235.8) | < 0.0001 |
| sFlt-1 (pg/ml)* | 4485 (4347 – 4628) | 7037 (6031 – 8212) | < 0.0001 | 6131 (5974 – 6291) | 12543 (11074 – 14207) | < 0.0001 |
| sFlt-1:PlGF ratio | 202.4 (196.0 – 209.0) | 294.6 (251.5 – 335.5) | < 0.0001 | 44.3 (42.9 – 45.7) | 58.7 (50.6 – 68.2) | 0.0003 |
| Gestational weeks mean (range) | 25.9 (24.8–28.1) | 35.1 (34.6–35.9) | ||||
|---|---|---|---|---|---|---|
| Singleton | Twin | p-value | Singleton | Twin | p-value | |
| n=2089 | n=91 | n=2064 | n=68 | |||
| PlGF (pg/ml)* | 445.9 (434.1 – 458.1) | 668.0 (587.2 – 759.9) | < 0.0001 | 350.2 (335.6 – 365.5) | 219.2 (173.2 – 277.3) | < 0.0001 |
| sFlt-1 (pg/ml)* | 5898 (5736 – 6065) | 12968 (11347 – 14821) | < 0.0001 | 10151 (9875 – 10435) | 36916 (31714 – 42971) | < 0.0001 |
| sFlt-1:PlGF ratio | 13.2 (12.7 – 13.7) | 19.4 (16.2 – 23.2) | < 0.0001 | 29.0 (27.3 – 30.7) | 168.4 (121.9 – 232.8) | < 0.0001 |
*
means (95% confidence intervals). Means are adjusted for gestational age from models with logarithm-transformed angiogenic factor as the outcome; presented are geometric means derived from taking the exponent of the adjusted mean. sFlt-1 (soluble fms-like tyrosine kinase-1; PlGF (placental growth factor)