Table 1.
Parasite and host cell receptors of invasion.
| Parasite Receptor |
EuPathDB | Host Cell Receptor | Structure |
|---|---|---|---|
| Duffy binding-like (DBL) family and erythrocyte binding-like (EBL) proteins | |||
| PfEBA-140 | PF3D7_1301600 | Glycophorin C | 4GF2 (Lin et al., 2012) (Region II) |
| 4JNO (Malpede et al., 2013) (Region II + sialyllactose) | |||
| PfEBA-175 (BAEBL) | PF3D7_0731500 | Glycophorin A | 1ZRL (Tolia et al., 2005) (Region II) |
| 1ZRO (Tolia et al., 2005) (Region II in presence of sialyllactose) | |||
| 2RJI (Withers-Martinez et al., 2008) (Region VI) | |||
| 4QEX, 4K4M, 4K2U (Chen et al., 2013) (Region II + Fab) | |||
| PfEBA-181 (JESEBL) | PF3D7_0102500 | unknown | -- |
| PvDBP | PVX_110810 | DARC | 3RRC (Batchelor et al., 2011) (Region II) |
| 4NUU (Batchelor et al., 2014) (Region II + DARC dimer) | |||
| 4NUV (Batchelor et al., 2014) (Region II dimer + DARC dimer) | |||
| PkαDBP | PKH_062300 | DARC | 2C6J (Singh et al., 2006) (Region II) |
| Reticulocyte (homolog) binding-like (RBL/RH) family | |||
| PfRH1 | PF3D7_0402300 | sialic-acid containing putative erythrocyte receptor Y | -- |
| PfRH2a | PF3D7_1335400 | chymotrypsin sensitive erythrocyte receptor Z | -- |
| PfRH2b | PF3D7_1335300 | chymotrypsin sensitive erythrocyte receptor Z | -- |
| PfRH4 | PF3D7_0424200 | Complement Receptor 1 (CD35) | 2Q7Z (Furtado et al., 2008) (30 SCR domains of HsCR1) |
| 2MCZ (Park et al., 2014) (SCR domains 1, 2 of HsCR1) | |||
| 2MCY (Park et al., 2014) (SCR domains 2, 3 of HsCR1) | |||
| PfRH5/PfRIPR | PF3D7_0424100 | Basigin (CD147/EMMPRIN) | 4U0Q (Wright et al., 2014a) (Region II + Basigin Domain Ig1&Ig2) |
| 4U0R, 4U1G (Wright et al., 2014a) (Region II + Fab) | |||
| 3QR2 (Redzic et al., 2011) (Basigin Ig0) | |||
| PvRBP1/2 | PVX_098585 | unknown | -- |
| Py235 | PY17X_1468100 | unknown | 3HGF (Gruber et al., 2010) (NBD94) |
| Thrombospondin related anonymous protein (TRAP) family | |||
| PfTRAP | PF3D7_1335900 | unknown | 4HQF, 4HQK (Song et al., 2012) (Closed form VWA + TSR domain) |
| 2BBX (Tossavainen et al., 2006) (TSR domain) | |||
| PvTRAP | PVX_082735 | unknown | 4HQL, 4HQN (Song et al., 2012) (Open form w/ Mg2+/Mn2+) |
| 4HQO (Song et al., 2012) (VWA + TSR) | |||
| 4F1K (Pihlajamaa et al., 2013) (VWA domain) | |||
| 4F1J (Pihlajamaa et al., 2013) (VWA domain+ Mg2+) | |||
| TgMIC2 | TGME49_201780 | unknown | 4OKR, 4OKU (Song and Springer, 2014) |
| 2XGG (Tonkin et al., 2010) (VWA domain) | |||
| PfMTRAP | PF3D7_1028700 | Semaphorin-7a (CD108) | 3NVQ (Liu et al., 2010) (Semaphorin-7a in complex with Plexin-C1) |
| PfTLP | PF3D7_0616500 | unknown | -- |
| PfCTRP | PF3D7_0315200 | unknown | -- |
| Apical membrane antigen (AMA) | |||
| PfAMA1 | PF3D7_1133400 | PfRON2* | 1Z40 (Bai et al., 2005) (Domains I&II) |
| 1YXE (Feng et al., 2005) (Domain II) | |||
| 1HN6 (Nair et al., 2002) (Domain III) | |||
| 3ZWZ (Vulliez-Le Normand et al., 2012) (Domains I&II + RON2 39 aa peptide) | |||
| 3SRI (Vulliez-Le Normand et al., 2012) (Domains I&II + RON2 29 aa peptide) | |||
| 3SRJ (Vulliez-Le Normand et al., 2012) (Domains I&II + inhibitory peptide) | |||
| 2Z8W, 2Z8V (Henderson et al., 2007) (Domains I&II + IgNAR) | |||
| 2Q8B, 2Q8A (Coley et al., 2007) (Domains I&II + Fab) | |||
| 2J5L (Igonet et al., 2007) (Fab + AMA1 region III peptide) | |||
| PvAMA1 | PVX_092275 | PvRON2* | 1W81, 1W8K (Pizarro et al., 2005) (Domains I,II,III) |
| 2J4W (Igonet et al., 2007) (Fab + AMA1 region III peptide) | |||
| 4UXKTBP(+RON2 29 aa peptide) | |||
| TgAMA1 | TGME49_255260 | TgRON2* | 2Y8R (Tonkin et al., 2011) (Y230A Domains I,II,III) |
| 2X2Z (Crawford et al., 2010) (Domains I,II,III) | |||
| 2Y8T (Tonkin et al., 2011) (Domains I,II,III + RON2 37 aa peptide) | |||
| 2Y8S (Tonkin et al., 2011) (Y230A Domains I,II,III + RON2 37 aa peptide) | |||
| TgsporoAMA1 | TGME49_115730 | TgsporoRON2* | 3ZLE (Poukchanski et al., 2013) (Domains I,II,III) |
| 3ZLD (Poukchanski et al., 2013) (Domains I,II,III + RON2 36 aa peptide) | |||
| BdAMA1 | BBOV_IV011230 | BdRON2 | 4APM (Tonkin et al., 2013) (Domains I,II,III) |
| NcAMA1 | NCLIV_028680 | NcRON2 | 4APL (Tonkin et al., 2013) (Domains I,II,III) |
*
RON2 is inserted into host cell membrane along with RON4, RON5, and RON8 (RON8 is not needed for Plasmodium spp.) forming a receptor for the parasite. RON2 is the only extracellular exposed protein.
TBPDeposited, Hold for Publication