Table 2.
Anatomic location and distribution of juxtacortical, subcortical, and periventricular white matter hyperintensities in migraine and control subjects*
| White matter hyperintensities | Control (n = 216) | Migraine without aura (n = 143) | Migraine with aura (n = 73) | P ≤† | ||||
|---|---|---|---|---|---|---|---|---|
| Juxtacortical WMHs | 0 (0) | 12 (8.4) | 6 (8.2) | .0001‡ | ||||
| Juxtacortical WMHs | Frontal | 0 (0) | 7 (4.9) | 3 (4.1) | .0001‡ | |||
| Parietal | 0 (0) | 4 (2.8) | 2 (2.7) | .03‡ | ||||
| Temporal | 0 (0) | 1 (0.7) | 1 (1.4) | NS | ||||
| Occipital | 0 (0) | 0 (0.5) | 0 (0.5) | - | ||||
| Juxtacortical WMHs | 0.0 ± 0.0 | 0 (0–0) | 0.1 ± 0.48 | 0 (0–3) | 0.14 ± 0.53 | 0 (0–3) | 0.0001‡ | |
| Juxtacortical WMHs | Frontal | 0.0 ± 0.0 | 0 (0–0) | 0.09 ± 0.41 | 0 (0–3) | 0.05 ± 0.28 | 0 (0–2) | 0.0001‡ |
| Parietal | 0.0 ± 0.0 | 0 (0–0) | 0.04 ± 0.26 | 0 (0–2) | 0.07 ± 0.42 | 0 (0–3) | .02‡ | |
| Temporal | 0.0 ± 0.0 | 0 (0–0) | 0.01 ± 0.08 | 0 (0–1) | 0.01 ± 0.12 | 0 (0–1) | NS | |
| Occipital | 0.0 ± 0.0 | 0 (0–0) | 0.0 ± 0.0 | 0 (0–0) | 0.0 ± 0.0 | 0 (0–0) | - | |
| Subcortical WMHs | 21 (9.7) | 41 (28.7 | 24 (32.9) | .0001‡ | ||||
| Subcortical WMHs | Frontal | 20 (9.3) | 36 (25.2) | 22 (30.1) | .0001‡ | |||
| Parietal | 6 (2.8) | 24 (16.8) | 13 (17.8) | .0001‡ | ||||
| Temporal | 0 (0) | 2 (1.4) | 4 (5.5) | .03‡ | ||||
| Occipital | 0 (0) | 1 (0.7) | 0 (0) | - | ||||
| Subcortical WMHs | 0.34 ± 1.28 | 0 (0–10) | 1.46 ± 2.9 | 0 (0–14) | 1.60 ± 2.99 | 0 (0–13) | 0.0001‡ | |
| Subcortical WMHs | Frontal | 0.31 ± 1.19 | 0 (0–10) | 0.94 ± 1.99 | 0 (0–11) | 1.10 ± 2.12 | 0 (0–11) | .0001‡ |
| Parietal | 0.03 ± 0.17 | 0 (0–1) | 0.47 ± 1.32 | 0 (0–8) | 0.42 ± 1.19 | 0 (0–8) | .0001‡ | |
| Temporal | 0.0 ± 0.0 | 0 (0–0) | 0.08 ± 0.36 | 0 (0–2) | 0.08 ± 0.36 | 0 (0–2) | 0.014‡ | |
| Occipital | 0.0 ± 0.0 | 0 (0–0) | 0.01 ± 0.17 | 0 (0–2) | 0.0 ± 0.0 | 0 (0–0) | NS | |
| Periventricular WMHs | 0 (0) | 0 (0) | 3 (4.1) | .04ǁ | ||||
| Periventricular WMH | Anterior | 0 (0) | 0 (0) | 3 (4.1) | .04ǁ | |||
| Posterior | 0 (0) | 0 (0) | 0 (0) | - | ||||
| Lateral | 0 (0) | 0 (0) | 0 (0) | - | ||||
| Periventricular WMHs | 0.0 ± 0.0 | 0 (0–0) | 0.0 ± 0.0 | 0 (0–0) | 0.04 ± 0.20 | 0 (0–1) | .02ǁ | |
| Periventricular WMHs | Anterior | 0.0 ± 0.0 | 0 (0–0) | 0.0 ± 0.0 | 0 (0–0) | 0.04 ± 0.20 | 0 (0–1) | .02ǁ |
| Posterior | 0.0 ± 0.0 | 0 (0–0) | 0.0 ± 0.0 | 0 (0–0) | 0.0 ± 0.0 | 0 (0–0) | - | |
| Lateral | 0.0 ± 0.0 | 0 (0–0) | 0.0 ± 0.0 | 0 (0–0) | 0.0 ± 0.0 | 0 (0–0) | - | |
*Data reported as number of patients (%), mean ± SD, or median (range, minimum to maximum). Abbreviation: WMHs deep white matter hyperintensities.
†NS, not significant (P > .05).
‡Comparison between control subjects and migraine patients (with and without aura).
ǁComparison between migraine patients with and without aura.