Table 7.
Performance of markers in primary and metastatic lung adenocarcinomas by bootstrap analysis
| Markers | Sensitivity | Specificity | ||
|---|---|---|---|---|
| Average ± SD | Range | Average ± SD | Range | |
| Primary ADCs | ||||
| TTF-1 | 0.848 ± 0.0446 | 0.690 – 0.972 | 0.934 ± 0.0438 | 0.800 – 1.000 |
| Napsin A | 0.919 ± 0.0545 | 0.720 – 1.000 | 1.000 ± 0.0000 | 1.000 – 1.000 |
| CK7 | 0.941 ± 0.0330 | 0.833 – 1.000 | 0.489 ± 0.1432 | 0.077 – 0.769 |
| TTF-1 + CK7 | 0.960 ± 0.0231 | 0.718 – 0.986 | 0.732 ± 0.0919 | 0.533 – 0.967 |
| TTF-1 + Napsin | 0.858 ± 0.0420 | 0.875 – 1.000 | 0.934 ± 0.0417 | 0.833 – 1.000 |
| TTF-1 + CK7 + Napsin A | 0.972 ± 0.0197 | 0.887 – 1.000 | 0.737 ± 0.0850 | 0.500 – 0.900 |
| Metastatic ADCs | ||||
| TTF-1 | 0.870 ± 0.0310 | 0.808 – 0.946 | 0.870 ± 0.1243 | 0.500 – 1.000 |
| Napsin A | 0.702 ± 0.0647 | 0.559 – 0.881 | 1.000 ± 0.0000 | 1.000 – 1.000 |
| CK7 | 1.000 ± 0.0000 | 1.000 – 1.000 | 0.285 ± 0.2358 | 0.000 – 1.000 |
| TTF-1 + CK7 | 0.992 ± 0.0086 | 0.969 – 1.000 | 0.624 ± 0.1662 | 0.125 – 1.000 |
| TTF-1 + Napsin | 0.878 ± 0.0298 | 0.794 – 0.939 | 0.881 ± 0.1286 | 0.375 – 1.000 |
| TTF-1 + CK7 + Napsin A | 0.993 ± 0.0072 | 0.969 – 1.000 | 0.618 ± 0.1793 | 0.125 – 1.000 |
ADC: adenocarcinoma. SqCC: squamous cell carcinoma.