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. 2015 Apr 28;4(4):e237. doi: 10.1038/mtna.2015.11

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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PEGylated MP7 directly blocks PD-1/PD-L1 binding. (a) Reaction scheme of aptamer conjugation to a 40 kDa polyethylene glycol (PEG) at the 5' termini. (b) The ability of PEGylated anti-PD-1 aptamers (PEG-MP5, PEG-MP7), PEG-cSeq, RPMI-14 mAb, or an isotype matched IgG control to inhibit the binding of soluble mPD-1.FcHIS to plate bound mPD-L1.Fc was determined using a competitive enzyme-linked immunosorbent assay utilizing an anti-HIS-HRP conjugated antibody. Each histogram bar represents the mean % of PD-1 blocked from binding PD-L1 ± SD (n = 3).