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. 2015 Mar 26;43(8):4039–4054. doi: 10.1093/nar/gkv252

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Guanine oxidation alters quadruplex folding and reduces the thermostability of quadruplexes. All samples were annealed in quadruplex folding buffer containing K⁺. CD spectra were recorded at 20°C. (A) The CD spectra of telomeric DNA with an 8-oxoG, Gh or Sp lesion at the 5′ position of a GGG triad (position 9). (B) The CD spectra of telomeric DNA with a guanine lesion in the middle of a GGG triad (position 10). (C) The CD spectra of telomeric DNA with a guanine lesion 3′ of a GGG triad (position 11). CD spectra for the Sp-containing quadruplexes were obtained on a mixture of diastereomers. (D) Guanine lesions reduce the thermostability of telomeric quadruplex DNA. Mean and standard deviation of the T_m values calculated from four experiments are shown.