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Long 5′-flaps inhibit the strand displacement activity of DNA polymerase δDV. (a) Schematic of the DNA substrates used. (b–d) DNA primer extension and strand displacement activity of Pol δDV in Buffer TM (20 mM NaCl, 30°C) as a function of the length (n) of the 5′-flap in the strand to be displaced, for different sizes of the gap in the substrate: (b) nick, (c) T1 gap and (d) T7 gap. In panel (d) the inhibitory role of a 20 nt 5′-flap of random sequence composition is shown as well.
