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. 2015 Apr 6;43(8):4075–4086. doi: 10.1093/nar/gkv273

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Candidate radiation sensitizing miRNA verification by MLuc assay and clonogenic survival assay. (A) LNCaP-MLuc (left) or PC3-MLuc (right) cell radiosensitivity following transfection with 20 nM of candidate miRNAs, negative control miRNA (cel-miR-239b) or positive control DNA-PK siRNA (siDNAPK). The% cell viability (mean ± SE, n = 3) following IR (4 Gy) represents the ratio of MLuc activity for irradiated cells to non-irradiated cells for each miRNA on day 11. Control miRNA is noted by the dash line. *, P < 0.05. The miRNAs were organized based on the PC3-MLuc cell radiosensitivity. (B) Clonogenic survival assay of DU145 cells transfected with 20 nM of candidate radiation sensitizing miRNAs or control miRNA. The surviving fraction is reported (mean ± SD, n = 3) following the indicated doses of IR. *, P < 0.05. DMF, Dose Modifying Factor.