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. 2015 Apr 6;43(8):4075–4086. doi: 10.1093/nar/gkv273

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — DSB repair delay by radiation sensitizing miRNAs. (A) Immunofluorescent staining of γ-H2AX foci (green) in DU145 cells transfected with control, miR-890 or miR-744–3p miRNAs in untreated (0 Gy) or 1 and 8 h after IR (4 Gy) treatment. Nuclei were stained with DAPI (blue). (B) Quantification of γ-H2AX foci. The percentage of cells containing >10 γ-H2AX foci (mean ± SE, n = 3) is reported for each time point and treatment group. *, P < 0.05. (C) Comet assay of DU145 cells transfected with control, miR-890 or miR-744–3p miRNAs which were either untreated (0 Gy) or 4 h after IR (4 Gy) treatment. (D) Quantification of the average tail moment (mean ± SE, n = 50) is reported for each miRNA and treatment condition. *, P < 0.05.