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. 2015 Apr 6;43(8):4075–4086. doi: 10.1093/nar/gkv273

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — miR-890 mimetic injection enhances IR therapy of established prostate tumors. (A) Established subcutaneous DU145 tumors (n = 3–5 per group) were directly injected with PBS or miRNA mimetics in neutral lipid emulsions. Two days after injection (day 0) tumors were irradiated with 6 Gy or no IR. miR-890 significantly reduced tumor volume in irradiated groups when compared to controls. ***P < 0.001, **P < 0.01, *P < 0.05; two-way ANOVA. Mean ± SEM. (B) Extension of tumor quadrupling for DU145 tumor model. Events (animals whose tumor volume was not yet 4-fold the size at injection) were plotted by Kaplan-Meier curve. miR-890 significantly extended time to tumor quadrupling in irradiated groups when compared to controls. P < 0.01; log-rank (Mantel-Cox) test.