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. 2015 Apr 21;14:91. doi: 10.1186/s12943-015-0365-6

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© Dong et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Klf5 deletion increases blood microvessels in mouse prostate tumors. H&E staining and IHC staining of Cd31 for blood microvessels from prostates at 8 months for Pten ^−/− (A) and 12 to 18 months for Pten ^+/− (B). Black arrows point to microvessels inside prostatic acini. Images at the right upper corner are higher magnifications of boxed areas. Microvessels were counted in dorsal lobes for Pten ^−/− prostates and the entire lobes for Pten ^+/− prostates. The total area of prostatic epithelia excluding the lumen space inside the acini was measured with ImageJ software. Gene status is indicated at the top of each panel, and + and – indicate wildtype and deletion of Klf5 or Pten, respectively. Three to 6 mice were used for each group. Microvessel density was defined by the number of microvessels per mm². *, P < 0.05; **, P < 0.01; N.S., not statistically significant.