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. 2015 Apr 21;14:91. doi: 10.1186/s12943-015-0365-6

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© Dong et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Klf5 deletion increases protein expression of Hif1α and pro-angiogenic factors. (A, B) IHC staining of Hif1α in mouse prostates at 4 months for Pten ^−/− and 12 months for Pten ^+/−. The numbers of Hif1α-positive cells and total prostatic epithelial cells were counted with ImageJ software for each mouse. (C, D) Protein expression of pro-angiogenic factors Vegf, Pdgf-d and Pdgf-b as detected by IHC staining with the same mouse tissues used in panels A and B. Three or 4 mice were used for each group. *, P < 0.05; **, P < 0.01; N.S., not statistically significant.