Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 21;14:91. doi: 10.1186/s12943-015-0365-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Dong et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

KLF5 decreases protein expression of HIF1α and secretion of pro-angiogenic factors. In PC-3 and DU 145 cells with stable knockdown (A), ectopic expression (B), RNAi-mediated transient knockdown (C), or adenovirus-mediated overexpression (D) of KLF5, HIF1α protein was detected by Western blotting whereas secretory pro-angiogenic factors PDGF-BB and VEGF in the conditioned media were detected by ELISA. shK1 and shK2 indicate 2 lentiviral shRNAs targeting KLF5 (sh36 and sh37), siK represents siRNA targeting KLF5 (siKLF5), and Ad-K represents adenovirus expressing KLF5. *, P < 0.05; **, P < 0.01; N.S., not statistically significant.