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. 2015 Apr 28;13:132. doi: 10.1186/s12967-015-0488-y

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© Sui et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of downregulated DNMT1 on cisplatin sensitivity of A549/DDP and SPC-A1/DDP cells. (A) A549/DDP cells were transfected with si-DNMT1. (B) 24 hours after incubation, the cell viability was assessed by MTT assay. (C) SPC-A1/DDP cells were also transfected with si-DNMT1 and (D) its cell viability was evaluated. Data were represented as mean ± SD. *P <0.05 compared with cells treated with the same concentration of ciaplatin accordingly.