Table 2.
Effect of bitter melon and glibenclamide on clinical/metabolic variables of study groups
| Variables | Baseline | Endpoint (week 10) |
|---|---|---|
| FPG (mg/dl) | ||
| Bitter melon 2 g/day (Group I) | 146±13.40 | 133.70±11.50*† |
| Bitter melon 4 g/day (Group II) | 141.60±15.20 | 126.40±11.90* |
| Glibenclamide 5 mg/day (Group III) | 143.50±18.40 | 117±10.30¤ |
| 2 h post OGTT plasma glucose (mg/dl) | ||
| Bitter melon 2 g/day (Group I) | 241.30±15.60 | 235±19.50 |
| Bitter melon 4 g/day (Group II) | 247±21.90 | 240.70±25.10 |
| Glibenclamide 5 mg/day (Group III) | 255.60±26.30 | 229.40±20.80* |
| T C (mg/dl) | ||
| Bitter melon 2 g/day (Group I) | 218.25±10.70 | 214.50±14.50 |
| Bitter melon 4 g/day (Group II) | 227.10±15.50 | 221±11.60 |
| Glibenclamide 5 mg/day (Group III) | 220.50±11.10 | 222±10.80 |
| LDL-c (mg/dl) | ||
| Bitter melon 2 g/day (Group I) | 149.70±18.20 | 146.50±11.50 |
| Bitter melon 4 g/day (Group II) | 154±15.50 | 148.90±16.40 |
| Glibenclamide 5 mg/day (Group III) | 146.80±10.30 | 148.50±12.35 |
| HDL-c (mg/dl) | ||
| Bitter melon 2 g/day (Group I) | 48.15±4.90 | 50±3.50 |
| Bitter melon 4 g/day (Group II) | 47.60±5.70 | 51.20±4.20 |
| Glibenclamide 5 mg/day (Group III) | 48.10±5.50 | 45±4.90 |
| T G (mg/dl) | ||
| Bitter melon 2 g/day (Group I) | 163.20±17.50 | 159.80±16.70 |
| Bitter melon 4 g/day (Group II) | 168±13.40 | 154.20±11.80* |
| Glibenclamide 5 mg/day (Group III) | 165.50±20.50 | 172.90±18.40 |
| T C/HDL-c ratio | ||
| Bitter melon 2 g/day (Group I) | 4.53±1.10 | 4.29±1.20 |
| Bitter melon 4 g/day (Group II) | 4.77±1.60 | 4.31±1.35 |
| Glibenclamide 5 mg/day (Group III) | 4.58±1.15 | 4.93±1.50 |
| LDL-c/HDL-c ratio | ||
| Bitter melon 2 g/day (Group I) | 3.10±1.35 | 2.93±1.10 |
| Bitter melon 4 g/day (Group II) | 3.23±1.52 | 2.89±1.31 |
| Glibenclamide 5 mg/day (Group III) | 3±1.47 | 3.30±1.20 |
| SBP (mmHg) | ||
| Bitter melon 2 g/day (Group I) | 139±8.10 | 135.50±11.90 |
| Bitter melon 4 g/day (Group II) | 144.80±23.70 | 133.10±14.30* |
| Glibenclamide 5 mg/day (Group III | 136.20±12.24 | 135.50±10.50 |
| Weight (Kg) | ||
| Bitter melon 2 g/day (Group I) | 69.50±10.70 | 67.65±11.32 |
| Bitter melon 4 g/day (Group II) | 73.90±12.20 | 70.80±10.50 |
| Glibenclamide 5 mg/day (Group III | 68.40±8.30 | 70±11.90 |
*p≤0.05 compared to baseline; ¤ p≤0.01 compared to baseline; † p≤0.05 compared to group III at week 10.