Table 3.

Empirical evaluation results—scenario (i), thresholds missing at random

% PTH decrease	Estimate of interest	Meta-analysis of the complete data	Meta-analysis of the datasets with missing threshold results, not including imputed results		Meta-analysis of the datasets with missing threshold results, including imputed results
		True estimate	Mean estimate across the 1,000 datasets	Median estimate across the 1,000 datasets	Mean estimate across the 1,000 datasets	Median estimate across the 1,000 datasets
40	Summary Sensitivity	0.87	0.88	0.90	0.88	0.90
		0.00	0.04	0.00	0.04	0.00
	s.e. (logit sensitivity)	0.40	0.70	0.62	0.70	0.62
	Summary specificity	0.52	0.52	0.52	0.52	0.52
		0.00	0.05	0.00	0.05	0.00
	s.e. (logit specificity)	0.18	0.25	0.24	0.25	0.24
50	Summary sensitivity	0.87	0.88	0.90	0.87	0.87
		0.00	0.04	0.00	0.04	0.00
	s.e. (logit sensitivity)	0.40	0.69	0.62	0.54	0.47
	Summary specificity	0.62	0.63	0.63	0.64	0.63
		0.00	0.05	0.01	0.04	0.00
	s.e. (logit specificity)	0.18	0.27	0.26	0.22	0.21
60	Summary sensitivity	0.87	0.88	0.90	0.87	0.86
		0.00	0.04	0.00	0.05	0.00
	s.e. (logit sensitivity)	0.40	0.69	0.62	0.52	0.43
	Summary specificity	0.78	0.78	0.79	0.78	0.77
		0.00	0.05	0.00	0.05	0.00
	s.e. (logit specificity)	0.21	0.31	0.29	0.24	0.23
65	Summary sensitivity	0.85	0.87	0.89	0.85	0.85
		0.00	0.04	0.00	0.05	0.00
	s.e. (logit sensitivity)	0.38	0.69	0.62	0.49	0.39
	Summary specificity	0.80	0.81	0.82	0.81	0.80
		0.00	0.05	0.00	0.04	0.00
	s.e. (logit specificity)	0.22	0.33	0.32	0.26	0.23
70	Summary sensitivity	0.85	0.86	0.88	0.83	0.84
		0.00	0.07	0.00	0.05	0.00
	s.e. (logit sensitivity)	0.38	0.68	0.64	0.47	0.39
	Summary specificity	0.85	0.86	0.86	0.85	0.85
		0.00	0.04	0.00	0.04	0.00
	s.e. (logit specificity)	0.25	0.36	0.35	0.30	0.26
80	Summary sensitivity	0.73	0.73	0.76	0.72	0.72
		0.00	0.04	0.00	0.05	0.00
	s.e. (logit sensitivity)	0.30	0.49	0.45	0.38	0.35
	Summary specificity	0.91	0.92	0.92	0.91	0.91
		0.00	0.04	0.00	0.04	0.00
	s.e. (logit specificity)	0.30	0.50	0.46	0.41	0.35
90	Summary sensitivity	0.55	0.51	0.55	0.51	0.55
		0.00	0.05	0.00	0.05	0.00
	s.e. (logit sensitivity)	0.27	0.46	0.36	0.46	0.36
	Summary specificity	0.96	0.96	0.96	0.96	0.96
		0.00	0.04	0.00	0.04	0.00
	s.e. (logit specificity)	0.46	0.69	0.59	0.69	0.59

NB All meta-analyses used model (2), as model (1) often poorly estimated ρ _10t as +1 or -1.