Table 1.

Effect of AHM and its fraction on brewer’s yeast-induced pyrexia

Treatment	Dose mg/kg	Body temp. (N)	Rectal temperature (°C)
			After administration of drug
			After 24 h (T)	1 h (P1)	2 h (P2)	3 h (P3)	4 h (P4)	5 h (P5)
Saline	10 ml	36.96 ± 0.21	38.96 ± 0.02	38.88 ± 0.09	38.73 ± 0.03	38.62 ± 0.02	38.55 ± 0.06	38.5 ± 0.014
Paracetamol	100	37.36 ± 0.25	39.35 ± 0.21	38.70 ± 0.27	37.99 ± 0.07*	37.79 ± 0.04*	37.49 ± 0.02**	37.395 ± 0.02***
AHM	50	37.23 ± 0.12	39.03 ± 0.06	39.32 ± 0.12	38.47 ± 0.084	38.15 ± 0.05	37.91 ± 0.03	37.77 ± 0.14
	100	36.85 ± 0.05	39.17 ± 0.08	39.05 ± 0.08	38.12 ± 0.021	37.94 ± 0.06	37.76 ± 0.05*	37.12 ± 0.03***
	150	37.30 ± 0.1	39.53 ± 0.18	39.20 ± 0.14	38.05 ± 0.09***	37.86 ± 0.04***	37.62 ± 0.03*	37.36 ± 0.06***
AHE	50	37.19 ± 0.10	39.43 ± 0.54	38.82 ± 0.41	38.01 ± 0.014	37.99 ± 0.01	37.68 ± 0.045*	37.24 ± 0.239***
	100	36.85 ± 0.05	38.67 ± 0.44	38.6 ± 0.489	37.88 ± 0.03*	37.475 ± 0.324**	37.31 ± 0.19***	36.75 ± 0.245***
	150	37.10 ± 0.10	39.18 ± 0.28	38.55 ± 0.45	37.62 ± 0.02**	37.625 ± 0.494**	37.195 ± 0.005***	37.13 ± 0.12***

Data values shown represent mean ± SEM (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001 versus only brewer’s yeast treated group (Two-way ANOVA followed by Bonferroni multiple comparison test). N indicates mean body temperature before pyrexia.