Table 5.
Effect of AHM and its fraction in hot plate test
| Group | Dose/route | Latency time in seconds | |||
|---|---|---|---|---|---|
| 0 min | 30 min | 60 min | 120 min | ||
| Saline | 10 ml, i.p. | 9.83 ± 0.601 | 9.36 ± 0.317 | 9.3. ± 0.881 | 9.167 ± 0.44 |
| AHM | 50 mg/kg, p.o. | 9.61 ± 0.1675 | 12.33 ± 0.881** | 17.00 ± 0.577*** | 18.33 ± 0.66*** |
| 100 mg/kg, p.o. | 9.76 ± 0.145 | 17.0 ± 0.57*** | 22.334 ± 1.201*** | 24.0 ± 0.557*** | |
| 150 mg/kg, p.o. | 9.74 ± 0.52 | 20.66 ± 0.881*** | 26.0 ± 0.577*** | 26.33 ± 0.334*** | |
| AHE | 50 mg/kg, p.o. | 9.63 ± 0.185 | 13.0 ± 0.577*** | 17.33 ± 0.667*** | 19.33 ± 0.333*** |
| 100 mg/kg, p.o. | 9.83 ± 0.167 | 17.66 ± 0.88*** | 23.0 ± 0.577*** | 24.33 ± 0.333*** | |
| 150 mg/kg, p.o. | 9.667 ± 0.166 | 22.0 ± 0.577*** | 26.66 ± 0.33*** | 27.0 ± 0.577*** | |
| Diclofenac sodium | 10 mg/kg, i.p. | 9.67 ± 0.667 | 21.66 ± 0.88*** | 26.16 ± 0.89*** | 26.66 ± 1.00*** |
| Fluoxetine | 10 mg/kg, i.p. | 9.66 ± 0.881 | 15.33 ± 0.334*** | 20.33 ± 0.90*** | 21.33 ± 0.667*** |
Data values shown represent mean ± SEM (n = 6). **p < 0.01, ***p < 0.001 versus saline treated group (Two-way ANOVA followed by Bonferroni multiple comparison test).