Table 3.

Correlations between DNA methylation levels of probes characterizing the epigenetic clustering in cancerous tissue samples and clinicopathological parameters of gastric cancers

Target ID a	Gene symbol	Predominant histological classificationb				Most aggressive histological classificationc			Tumor stage			Pathological Tumor-Node-Metastasis stage
		Average βT d			P valueh	Average βT d		P valuei	Average βT d		P valuei	Average βT d			P valueh
		Diff.e	Undiff.f	Mucing		Diff.e	Undiff.f		pT1–pT2	pT3–pT4		IA–IB	IIA–IIB	IIIA–IV
(A) Probes listed in Table 2A
cg23743114	CCL15 − CCL14	0.398	0.460	0.351	7.71×10−2	0.372	0.443	2.07×10−2	0.430	0.422	8.12×10−1	0.423	0.430	0.423	9.82×10−1
cg02192965	SLC3A1	0.406	0.516	0.425	2.63×10−3	0.381	0.483	2.08×10−2	0.425	0.465	3.01×10−1	0.411	0.497	0.459	2.56×10−1
cg14934821	GPSM1	0.531	0.566	0.482	4.65×10−1	0.535	0.549	7.28×10−1	0.458	0.571	6.91×10−4	0.467	0.548	0.571	4.28×10−2
cg07220939	SLC22A12	0.316	0.418	0.413	2.00×10−2	0.296	0.389	1.81×10−2	0.374	0.362	7.97×10−1	0.357	0.429	0.349	2.73×10−1
cg26530341	LOC389641	0.392	0.450	0.388	9.32×10−2	0.375	0.433	4.68×10−2	0.365	0.433	1.97×10−2	0.370	0.423	0.432	1.76×10−1
cg04968426	PPP1R14D	0.625	0.714	0.666	2.52×10−2	0.590	0.694	9.07×10−3	0.632	0.676	2.69×10−1	0.618	0.677	0.679	3.31×10−1
cg03545635	CHST12	0.712	0.734	0.682	4.51×10−1	0.712	0.725	5.58×10−1	0.681	0.733	3.55×10−2	0.680	0.735	0.731	1.06×10−1
cg07150830	NOS2	0.670	0.779	0.629	5.39×10−3	0.661	0.738	3.79×10−2	0.691	0.725	4.00×10−1	0.687	0.659	0.744	1.37×10−1
cg21122774	SARDH	0.528	0.633	0.492	4.43×10−3	0.523	0.593	4.29×10−2	0.508	0.593	1.70×10−2	0.496	0.605	0.592	4.51×10−2
cg17778120	RBP2	0.589	0.670	0.699	2.89×10−2	0.596	0.640	2.07×10−1	0.611	0.634	5.29×10−1	0.606	0.620	0.638	7.02×10−1
cg09081544	MUC13	0.448	0.526	0.443	4.16×10−2	0.443	0.497	1.11×10−1	0.463	0.489	4.63×10−1	0.455	0.501	0.487	6.35×10−1
cg09448875	ABCC2	0.423	0.512	0.428	1.34×10−2	0.419	0.479	7.36×10−2	0.450	0.467	6.19×10−1	0.441	0.490	0.464	6.15×10−1
cg03077492	CCL28	0.773	0.817	0.736	8.63×10−2	0.764	0.802	1.56×10−1	0.744	0.806	3.49×10−2	0.752	0.792	0.805	1.42×10−1
cg24027679	SLC2A7	0.630	0.696	0.631	9.85×10−2	0.629	0.671	2.42×10−1	0.604	0.676	4.02×10−2	0.587	0.692	0.675	4.43×10−2
cg20683151	TM4SF20	0.591	0.668	0.570	3.74×10−2	0.574	0.643	5.37×10−2	0.624	0.625	9.87×10−1	0.619	0.650	0.620	7.70×10−1
cg21591452	TMEM105	0.683	0.777	0.730	8.61×10−3	0.649	0.755	3.12×10−3	0.721	0.728	8.55×10−1	0.713	0.733	0.730	8.91×10−1
cg06277277	NR1I3	0.512	0.625	0.565	7.81×10−4	0.525	0.578	1.27×10−1	0.570	0.562	8.13×10−1	0.565	0.547	0.568	8.76×10−1
cg11920519	MAP1LC3A	0.562	0.661	0.530	1.31×10−2	0.552	0.625	6.41×10−2	0.602	0.607	9.16×10−1	0.594	0.611	0.608	9.43×10−1
cg16575408	MMP1	0.682	0.760	0.620	3.56×10−2	0.643	0.741	1.01×10−2	0.677	0.726	2.58×10−1	0.673	0.708	0.731	3.64×10−1
(B) Probes listed in Table 2B
cg11657808	RYR2	0.686	0.618	0.636	1.27×10−2	0.709	0.634	2.91×10−2	0.692	0.643	1.32×10−1	0.686	0.621	0.652	4.83×10−1
cg11939071	DTX1	0.328	0.409	0.517	1.08×10−2	0.280	0.402	1.69×10−2	0.452	0.345	2.69×10−2	0.442	0.353	0.350	2.50×10−1
cg22619018	CSMD1	0.576	0.632	0.638	5.39×10−2	0.572	0.614	4.76×10−1	0.701	0.574	2.30×10−2	0.698	0.519	0.594	8.28×10−2
cg18671950	FBN1	0.511	0.466	0.594	3.02×10−2	0.533	0.479	1.61×10−1	0.554	0.475	1.31×10−2	0.553	0.452	0.484	1.87×10−1
cg08383315	RIC3	0.459	0.426	0.505	5.64×10−2	0.479	0.433	2.47×10−1	0.517	0.424	1.25×10−2	0.510	0.401	0.436	1.34×10−1

^aProbe ID for the Infinium HumanMethylation27 Bead Array.

^bIf the tumor showed heterogeneity, findings in the predominant area were described.

^cIf the tumor showed heterogeneity, the most aggressive features of the tumor were described.

^dAverage DNA methylation levels in T samples.

^eDifferentiated. ^fUndifferentiated. ^gMucin-producing.

^h P values (ANOVA) and ⁱWelch’s t test (P values of < 0.05 are underlined).