Table 4.
Multivariate analyses using the Cox proportional hazards regression model for recurrence and disease-related death of patients with gastric cancers
| Probe IDa | Gene symbol | Recurrenceb | Disease-related deathb | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| β values in T samplesc | Predominant histologyd | Most aggressive histologye | pTf | TNM stageg | β values in T samplesc | Predominant histologyd | Most aggressive histologye | pTf | TNM stageg | ||
| cg24687051 | KCNQ5 | 4.75×10−2 | 0.587 | 0.647 | 0.846 | 4.52×10−3 | 0.177 | 0.613 | 0.384 | 0.815 | 6.25×10−4 |
| cg03168582 | DMRT1 | 1.50×10−4 | 0.774 | 0.612 | 0.961 | 1.71×10−3 | 6.05×10−3 | 0.841 | 0.356 | 0.910 | 3.33×10−4 |
| cg07080358 | CNRIP1 | 3.64×10−2 | 0.444 | 0.670 | 0.842 | 2.29×10−3 | 7.49×10−2 | 0.501 | 0.458 | 0.816 | 3.41×10−4 |
| cg11939071 | DTX1 | 2.37×10−3 | 0.672 | 0.141 | 0.824 | 2.18×10−3 | 5.37×10−2 | 0.662 | 0.126 | 0.941 | 4.25×10−4 |
| cg22029275 | AMER2 | 5.30×10−2 | 0.270 | 0.328 | 0.706 | 5.68×10−3 | 4.38×10−2 | 0.368 | 0.226 | 0.766 | 4.65×10−4 |
| cg22619018 | CSMD1 | 8.17×10−3 | 0.433 | 0.420 | 0.854 | 1.66×10−3 | 3.14×10−2 | 0.545 | 0.211 | 0.989 | 2.40×10−4 |
| cg12629325 | PCDHAC1 | 3.28×10−2 | 0.409 | 0.442 | 0.758 | 6.56×10−3 | 4.47×10−2 | 0.539 | 0.349 | 0.804 | 5.81×10−4 |
| cg17872757 | FLI1 | 6.86×10−2 | 0.582 | 0.643 | 0.761 | 5.02×10−3 | 2.94×10−2 | 0.680 | 0.443 | 0.794 | 4.83×10−4 |
| cg13562911 | ELOVL2-AS1 | 8.84×10−3 | 0.346 | 0.205 | 0.742 | 4.64×10−3 | 3.73×10−2 | 0.433 | 0.151 | 0.729 | 7.11×10−4 |
| cg18671950 | FBN1 | 3.70×10−2 | 0.357 | 0.635 | 0.955 | 2.89×10−3 | 8.95×10−2 | 0.464 | 0.326 | 0.883 | 4.31×10−4 |
| cg25583174 | FGF2 | 2.17×10−2 | 0.311 | 0.279 | 0.913 | 2.77×10−3 | 6.89×10−2 | 0.426 | 0.230 | 0.857 | 3.44×10−4 |
| cg20415809 | ITGA4 | 4.36×10−2 | 0.365 | 0.521 | 0.803 | 3.28×10−3 | 1.39×10−2 | 0.476 | 0.365 | 0.810 | 3.59×10−4 |
| cg16778809 | ADAM23 | 8.41×10−3 | 0.867 | 0.717 | 0.916 | 2.81×10−3 | 5.10×10−2 | 0.993 | 0.500 | 0.824 | 4.64×10−4 |
aProbe ID for the Infinium HumanMethylation27 Bead Array.
b P values of <0.05 are underlined.
cAverage DNA methylation levels in T samples (cut-off value ≤βT or >βT).
dHistological classification (differentiated, undifferentiated or mucin-producing). If the tumor showed heterogeneity, findings in the predominant area were described.
eHistological classification (differentiated, undifferentiated or mucin-producing). If the tumor showed heterogeneity, the most aggressive features of the tumor were described.
fTumor stage (pT1–pT2 or pT3–pT4).
gPathological Tumor-Node-Metastasis stage (IA–IB, IIA–IIB or IIIA–IV).